清华大学化学系刘冬生教授10月15日上午学术报告

发布时间:2009-10-11访问量:46设置

 

人:刘冬生  教授

                    清华大学化学系

报告题目Nanodevices and smart materials based on DNA i-motif structures

报告时间:1015日上午1000

报告地点:FUNSOM实验室208报告室(材料大楼910号楼)

 

摘要:

The molecular recognition properties of DNA are sufficiently well understood to enable the self-assembly of defined structures on the nanometer scale.[1]  DNA nanostructures have the potential to form the next generation of functional devices.  An important challenge is to fabricate molecular components that act as machines.[2] Based on the i-motif structure, a DNA quadruplex which is formed by DNA containing stretches of cytosine under slight acidic conditions, we have demonstrated a pH-change driven DNA nanomotor. Each working cycle of this motor could be finished in seconds and the by-product is H2O plus salt, multiple cycling of this machine has also been demonstrated.[3] We have also shown the working ability of this nanomotor in the solid/liquid interface[4] as well as driving a microcantilever move.[5]  In this talk, we will show its application in fabricating smart devices such as pH trigged DNA nanocompartment[6], enthalpy-driven three-State switching of superhydrophilic/ superhydrophobic surface[7], as well as photo-pH dually modulated fluorescence switch and controllable assembly of gold nanoparticles.[8]

 

 




[1]   N. C. Seeman, Nature 2003, 421, 427-431.

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