哥伦比亚大学Lance Cameron Kam副教授3月20日上午学术报告

发布时间:2014-03-14访问量:94设置

报告人:Lance Cameron Kam 副教授

 

Department of Biomedical Engineering,

Columbia University, USA

 

题目:  Improving Cellular Immunotherapy Through Engineering

时间:2014320(星期四)上午900

地点:909号楼一楼B会议室(Conference Room B, 909-1F)

 

个人简历:

A.   Positions and Honors

Positions and Employment

1991-1994           Graduate Research Assistant, Department of Mechanical Engineering, University of Hawaii

1994-1999           Graduate Research Assistant, Wadsworth Center, Albany, NY

1999-2003           Postdoctoral Fellow, Department of Chemistry, Stanford University

2003-2012           Assistant Professor, Department of Biomedical Engineering, Columbia University

2012-                   Associate Professor, Department of Biomedical Engineering, Columbia University

Honors

2000-2001           Postdoctoral Fellow, NIH Genome Training Program, Stanford University 

2001-2002           Postdoctoral Fellow, National Institutes of Health

2002-2003           Co-investigator, Bio-X Interdisciplinary Initiatives Award, Stanford University

2006                    PI, Pilot award, Gatsby Initiative in Brain Circuitry

2008                    PI, Research Initiatives in Science and Engineering

2008                    Discussion leader, Gordon Research Conference on Biointerfaces

2011                    Rising Star recognition, Society for Physical Regulation of Biology and Medicine

 

B. Selected Peer-Reviewed Publications (of 43)

1.      Bashour, K.T., Gondarenko, A., Chen, C., Shen, K., Liu, X., Huse, M., Hone, J.C., and Kam, L.C., “CD28 and CD3 have complementary roles in T-cell traction forces”, Proceedings of the National Academy of Sciences, USA, ahead of print,(2014).

2.      Bashour, K.T., Tsai, J., Shen, K., Lee, J-H., Sun, E., Milone, M.C., Dustin, M.L., and Kam, L.C., “Crosstalk between CD3 and CD28 is spatially modulated by protein lateral mobility”, Mol Cell Biol, ahead of print, (2013).

3.      Choudhuri, K., Llodrá, J., Roth, E.W.G., Tsai, J., Gordo, S., Wucherpfennig, K.W., Kam, L.C., Stokes, D.L., and Dustin, M.L., “Polarized release of TCR-enriched microvesicles at the center of the T cell immunological synapse”, Nature, accepted for publication, (2014).

4.      Wang, Y., Xu, Z., Kam, L.C., and Shi, P., "Site-Specific Differentiation of Neural Stem Cell Regulated by Micropatterned Multicomponent Interfaces.", Adv Healthca Mat, 3:214 (2014).

5.      Judokusumo, E., Tabdanov, E., Kumari, S., Dustin, M.L., and Kam, L.C., “Mechanosensing in T Lymphocyte Activation”, Biophysical Journal – Letters102:L5-7 (2012).

6.      O'Connor, R.S., Hao, X., Shen, K., Bashour, K., Akimova, T., Hancock, W.W., Kam, L.C., Milone, M.C., "Substrate rigidity regulates human T cell activation and proliferation.", J Immunol, 189:1330-9 (2012).

7.      Tsai, J., and Kam, L.C., ““Rigidity-dependent crosstalk between integrin and cadherin signaling.” Biophysical Journal-Biophysical Letters, 96: L39-41 (2009).

8.      Shen, K., Thomas,V.K., Dustin, M.L., and Kam, L.C., “Micropatterning of Costimulatory Ligands Enhances CD4+ T Cell Function.” Proceedings of the National Academy of Sciences, USA, 105:7791-6 (2008).

9.      Shi, P., Shen, K., Ghassemi, S., Hone, J., and Kam, L.C., "Dynamic Force Generation by Neural Stem Cells", Cell Molec Bioeng, 2: 464-74 (2009).

10.  Kam, L.C., “Capturing the nanoscale complexity of cellular membranes in supported lipid bilayers”, J Struct Biol, 168: 3-10 (2009).

11.  Shen, K., Tsai, J., Shi, P., and Kam, L.C. “Self-aligned supported lipid bilayers for patterning the cell-substrate interface”, J Am Chem Soc. – Communications, 131: 13204-5 (2009).

12.  Tsai, J., Sun, E., Gao, Y., Hone, J.C., and Kam, L.C., “Non-brownian diffusion of membrane molecules in nanopatterned supported lipid bilayers.” Nano Lett, 8: 425-30 (2008).

13.  Shi, P., Shen, K., and Kam L.C., “Local presentation of L1 and N-cadherin in multicomponent, microscale patterns differentially direct neuron function in vitro.” Dev Neurobiol, 67: 1765-76 (2007).

14.  Perez, T.D., Nelson, W.J., Boxer, S.G., and Kam, L. “E-cadherin tethered to supported lipid bilayers as a model for cell adhesion,” Langmuir, 21: 11963-8 (2005).

15.  Kam, L., and Boxer, S.G., “Spatially Selective Manipulation of Supported Lipid Bilayers by Laminar Flow: Steps Towards Biomembrane Microfluidics,” Langmuir, 19: 1624-1631 (2003).

 

C. Pending and Issued Patents

1. Milone, M.C, Shen, K., and Kam, L.C., “Ex vivo activation and expansion of human T cell subsets using biocompatible solid substrates with tunable rigidity”, Provisional (2011).

2. Kam, L., Shen, K., Dustin, M.L., Thomas, V.K., “Micropatterned T cell stimulation”, Pending, US Patent application 20080317724 (2009).

3.  Boxer, S.G., and Kam, L., “Biosensor arrays and methods”, US Patent No. 6,503,452 (2000).

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