Research Laboratory for Biomedical Optics and Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Boulevard, Nanshan, Shenzhen 518055, China
题目: Multi-scale molecular and functional photoacoustic imaging
地点：910号楼308会议室(Conference Room 308, 910-3F)
While super-resolution imaging has broken through the optical diffraction limit to enable our visualization of the sub-cellular world in live cells, photoacoustic imaging has broken through the optical diffusion limit to allow us seeing intact biological tissue in vivo at an unprecedented depth (up to several cm) with rich optical contrasts. As a result, photoacoustic imaging can provide anatomic, functional, and molecular information on biological tissue at multiple scales from organelles to organs. In this talk, we will present our development of acoustic- and optical-resolution photoacoustic microscopy technologies that can offer multi-scale molecular and functional information about intact biological tissue. In conjunction with optically absorbing molecular probes, acoustic-resolution photoacoustic microscopy can penetrate deep to provide a macroscopic view of the disease status. On the other hand, their optical-resolution counter-part can offer optical-diffraction limited spatial resolution to visualize microscopic vascular functional changes using endogenous contrast. Example applications of the developed technologies in molecular and functional imaging of cancer and atherosclerotic plaques will be discussed.
Liang Song is Associate Professor and Founding Director of the Research Laboratory for Biomedical Optics and Molecular Imaging at the Shenzhen Institutes of Advanced Technology (SIAT), the Chinese Academy of Sciences (CAS). In addition, he directs the Shenzhen Key Laboratory for Molecular Imaging. Prior to joining SIAT, he studied at Washington University in St. Louis and received his Ph.D. in Biomedical Engineering in 2010 (with Professor Lihong Wang). He has invented and/or developed several novel photoacoustic tomography (PAT) technologies, including high-speed PAT with advanced compressed sensing techniques and intravascular optical-resolution PAT. He has authored and co-authored more than 20 peer-reviewed journal articles in Biomaterials, PLOS ONE, Optics Letters, and Optics Express etc., which have been cited by prestigious journals such as Science, Nature Medicine, Chemical Reviews, etc.. He has two US and >10 Chinese Patents pending, and two invited book chapters forthcoming. He serves as regular reviewers for multiple international academic journals and is a member of IEEE, OSA, and SPIE. His research on PAT has been supported by >8 million RMB with grants from NSFC, MOST, CAS, and the Shenzhen Municipal Government.