Department of Materials Science and Engineering,
University of Illinois at Urbana-Champaign, Urbana, Illinois 61821, USA
题目：Design of Translational Anticancer Nanomedicines through Controlled Chemistry
地点：909号楼一楼B会议室(Conference Room B, 909-1F)
Nanomedicine is a new modality for cancer diagnosis and therapy and may change the landscape of oncology. In this seminar I will cover two major topics related to anticancer nanomedicine. First, I will present the development of conjugated polymeric particles for drug delivery applications. Specifically, I will report drug-initiated polymerization of lactide for the synthesis of polymeric nanoconjugates. Our recent development of chain-shattering polymeric therapeutics and polymer/drug nanocystals will also be covered as new nanostructures to provide precisely controlled drug release. For the second topic, I will discuss the transformation of conventional silica nanoparticles to advanced nanomedicines. Specifically, I will present the design and synthesis of size precisely controlled silica nanoconjugates and their applications as drug delivery nanomedicine, and discuss the use of these size controlled silica nanoconjugates in various fundamental studies, such as cellular uptake, biodistribution, tumor tissue penetration and inhibition.
Jianjun Cheng obtained a B.S. degree in Chemistry from Nankai University, China, in 1993, a M.S. degree in chemistry from Southern Illinois University at Carbondale in 1996, and a Ph.D. degree in materials science from the University of California, Santa Barbara in 2001 with Professor Timothy Deming. He was a senior scientist at Insert Therapeutics, Inc. from 2001 to 2004, and a postdoctoral fellow at MIT with Professor Robert Langer from 2004 to 2005. He joined the faculty of the University of Illinois at Urbana-Champaign (UIUC) in 2005 and is currently an Associate Professor of Materials Science and Engineering and a Willett Faculty Scholar of UIUC. Dr. Cheng is the co-inventor of 22 patents and the co-author of over 100 publications. He received a Prostate Cancer Foundation Competitive Award in 2007, a National Science Foundation CAREER Award in 2008, Teaching Excellence Awards at UIUC for five times in 2008-2010, a Xerox Award for Outstanding Research at UIUC in 2010, and a NIH Director’s New Innovator Award in 2010. He is appointed as an Associate of Center for Advanced Study, UIUC, in 2014. Dr. Cheng is currently an Associate Editor of Biomaterials Science, Royal Society of Chemistry.