报告人：Marie-Louise Saboungi 教授
IMPMC - Université Pierre et Marie Curie, Paris; Université d'Orléans, France
题目：MAGNETIC NANOPARTICLES IN BIOMEDICINE
Recent years have seen heightened applications of magnetic nanoparticles (NPs) in biomedicine. Most of these involve iron oxide nanoparticles in the superparamagnetic (SPM) state, in which the particles behave as paramagnets with a huge magnetic moment.1-5 The applications can be roughly divided into three groups:
1. Imaging using magnetic nanoparticles, where SPM NPs are used as contrast agents in magnetic resonance imaging because of their large magnetic moments in a static magnetic field.
2. Magnetic targeting for drug and gene delivery, which can be effected in a number of different ways: a) thermomagnetic activation, in which fast relaxation of SPM NPs leads to local heating and hence drug or gene release; b) Direct magnetic activation with a rotating magnetic field; and c) magnetic guiding to critical locations with an strong external magnetic field.
3. Hyperthermia therapy, which, between 40 and 43° C, stimulates the immune system of the patient for an anticancer response, generally associated with radiotherapy or chemotherapy.
In this talk I will briefly summarize progress in these areas and proceed to a more detailed
discussion of two avenues recently explored.
(1) Hervé K, Douziech-Eyrolles L, Munnier E, Cohen-Jonathan S, Soucé M, Marchais H, Limelette P, Warmont
F, Saboungi ML, Dubois P, Chourpa I, The development of stable aqueous suspensions of PEGylated SPIONs
for biomedical applications. Nanotechnology, 2008, 19: 465608.
(2) K. Kaaki, K. Hervé-Aubert, M. Chiper, A.Shkilnyy, M. Soucé, R. Benoit, A. Paillard, P. Dubois, M.L.
Saboungi, I. Chourpa, Magnetic nanocarriers of doxorubicin coated with poly(ethylene glycol) and folic acid:
relation between coating structure, surface properties, colloidal stability and cancer cell targeting, Langmuir,
2012, 28: 1496-1505.
(3) Gautier J, Munnier E, Paillard A, Hervé K, Douziech-Eyrolles L, Soucé M, Dubois P, Chourpa I, A
pharmaceutical study of doxorubicin-loaded PEGylated nanoparticles for magnetic drug targeting, Int J Pharm,
(4) I. Milosevic, S. Guillot, M. Tadic, M. Duttine, E. Duguet, K. Pierzchala, A. Sienkiewicz, L. Forro, M.-L.
Saboungi, J.-P. Salvetat, Loading and release of internally self-assembled emulsions embedded in a magnetic
hydrogel, Appl Phys Letters, 2014, 104: 043701.
(5) I. Milosevic, 2012, PhD thesis, University of Orléans, France.
Marie-Louise Saboungi is Professor of Condensed Matter Physics at the French Universities and shares her research between the University of Orleans, the CNRS and the Pierre et Marie Curie University in Paris. She served as Director of a research institute in Orleans (CRMD) for 10 years and as Co-Director of the Materials, Energy and Geosciences Thrust Area at Orleans. Prior to that she was a Senior Scientist at Argonne National Laboratory near Chicago, where she established close collaborations with the University of Chicago’s James Franck Institute and with Cornell University’s Food Sciences Department. She is a Fellow of the American Association for the Advancement of Science, the American Physical Society and the Alexander von Humboldt Foundation, from which she received the Helmholtz-Humboldt Prize in 2008. She has served on international advisory committees as well as national committees in the US for the Department of Energy and the National Science Foundation, in France for the CNRS and AERES, and in the European Community. She actively participated in the Association of Women in Science and received an Award for Leadership in the Professions from the YWCA of Metropolitan Chicago.