美国伊利诺伊大学厄巴纳-香槟分校博士后白玉罡5月8日上午学术报告

发布时间:2015-04-23访问量:237设置

报告人:白玉罡

 

Zimmerman Group in Department of Chemistry, University of Illinois at Urbana-Champaign

 

题目:DEVELOPMENT OF POLYNORBORNENES AND POLYPEPTIDES

            AS VERSATILE FUNCTIONAL BIOMATERIALS

时间:201558日(星期五)9:30am

地点:独墅湖校区910号楼308会议室

 

摘要:

Two example syntheses of useful polymeric materials will be described. The first part involves a new approach to prepare functional organic nanoparticles (ONPs) by consecutive ring-opening metathesis polymerization (ROMP) and intramolecular ring-closing metathesis (RCM). This flexible and mild synthesis allows preparation of organic- and aqueous-soluble particles with controllable size and narrow molecular weight distributions. Such non-toxic ONPs can be used to study the effect of surface functional groups on the cellular uptake of corresponding nanoparticles. In addition, dye functionalized ONPs can serve as water-soluble fluorophores with highly enhanced photostability. Moreover, other functional materials such DNAs can be conjugated to the ONPs, bringing in new hybrid materials. The ONPs and ONP-DNA conjugates can also serve as templates for the synthesis of metal nanoparticles, providing a direct and facile synthetic route for functional metal nanoparticles. The second part majorly focuses on a polymeric approach to enhance the efficacy of toxic (CUG)n-binding compounds for potential Myotonic Dystrophy Type I treatment. Also using a bottom-up synthetic strategy, cell-penetrating polymers bearing active binding ligands are prepared. The synthetic polypeptide binder is shown to have excellent performance in both molecular and cell studies, giving much enhanced binding to the toxic RNA, successful nuclear foci dispersion, and full reversal on IR-mRNA splicing in the model cells.

 

个人简介:

Dr. Yugang Bai was born in Zhengzhou, China. He obtained a B. S. degree of chemistry at Nanjing University in 2009, and moved to the United States for Ph. D. study. He spent one and a half year in the Cheng Group, Department of Materials Science and Engineering at University of Illinois at Urbana-Champaign, doing research related to hybrid polymeric materials based on synthetic functional polypeptides. He then moved to the Zimmerman Group in Department of Chemistry on the same campus in 2011, and worked on the synthesis and application of polynorbornene and polypeptide biomaterials. He obtained his Ph. D. degree of chemistry in 2015, and continued as a postdoc researcher in the Zimmerman Lab.

 

联络人:殷黎晨教授


 

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