报告人：Prof. Jianjun Cheng
Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
题目：Transforming Conventional Materials through Rational Design and Controlled Synthesis
I will cover three topics in my presentation to highlight research progress in my group in the past 3-4 years. I will first present the development of charged, helical polypeptides and their applications in gene delivery, bacterial inhibition and cell membrane penetration. We successfully transformed the conventional polypeptides to highly useful materials with exceptional biological membrane activities that can undergo direct membrane pore formation in energy-independent manner. I will also present rational design of helix-to-coil and coil-to-helix transitions of polypeptides and their applications in unpackaging DNA, lowering intracellular toxicity and inhibiting bacterial at extreme pH. For the second topic, I will discuss the transformation of conventional silica nanoparticles to advanced nanomedicines. Specifically, I will present the design and synthesis of size precisely controlled silica nanoconjugates and their applications as drug delivery nanomedicine, and discuss the use of these size controlled silica nanoconjugates in various fundamental studies, such as cellular uptake, biodistribution, tumor tissue penetration and inhibition. I will then cover the third topic in the last part of my presentation and discuss our recent efforts on transforming conventional urea-based polymeric materials to functional polymers. Specifically, I will present the design of hindered urea bonds and the dynamic chemistry associated with these bonds. Using the reversible, dynamic hindered urea bonds, we successfully developed polymers capable of catalyst-free dynamic property change and autonomous repairing at low temperature. I will also briefly discuss the use of polymers containing hindered urea bonds as biomaterials for controlled release and drug delivery applications.
Jianjun Cheng obtained a B.S. degree in Chemistry from Nankai University, China, in 1993, a M.S. degree in Chemistry from Southern Illinois University at Carbondale in 1996, and a Ph.D. degree in Materials Science from the University of California, Santa Barbara in 2001 with Professor Timothy Deming. He was a Senior Scientist at Insert Therapeutics, Inc. from 2001 to 2004, and a Postdoctoral Research Scientist at MIT with Professor Robert Langer from 2004 to 2005. He joined the faculty of the University of Illinois at Urbana-Champaign (UIUC) as a tenure-track Assistant Professor in 2005, and was promoted to Associate Professor in 2011 and Full Professor in 2015. Cheng is the co-inventor of 24 patents and co-authored over 130 publications. Cheng’s research has made translational impact. Two nanomedicine systems he developed/co-developed are currently in Phase-II clinical trials. He received a Prostate Cancer Foundation Competitive Award in 2007, a National Science Foundation CAREER Award in 2008, a Xerox Award for Outstanding Research at UIUC in 2010, a NIH Director’s New Innovator Award in 2010, the Willett Faculty Scholar Award in 2013, and the UIUC Distinguished Promotion Award in 2015 (among 5 out of 80 faculties being promoted). He was appointed as an Associate of Center for Advanced Study, UIUC, in 2014. He has also been on the list of Teacher Ranked As Excellent By Their Students five times at UIUC. Cheng is currently an Associate Editor of Biomaterials Science, Royal Society of Chemistry. He is a Fellow of the American Institute for Medical and Biological Engineering and American Chemical Society-Division of Polymer Chemistry.