Facile Preparation of Multifunctional Upconversion Nanoprobes for Multimodal Imaging and Dual-Targeted Photothermal Therapy
Liang Cheng,1 Kai Yang,1 Yonggang Li,2 Jianhua Chen,2 Chao Wang,1 Mingwang Shao,1,* Shuit-Tong Lee,3 and Zhuang Liu1,*
1 Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu 215123 (China)
2 Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006 (China)
3 Center of Super-Diamond and Advanced Films (COSDAF) and Department of Physics and Materials Science, City University of Hong Kong, Hong Kong SAR (China)
A multifunctional nanoparticle (MFNP) integrates an upconversion nanoparticle (see picture, green), a layer of iron oxide nanoparticles (black), and a gold shell (red). The system can be used for in vitro targeted upconversion luminescence, magnetic resonance, and light scattering multimodal imaging of cells. The near-infrared optical absorption of MFNPs also enables photothermal destruction of cancer cells.