Multimodal Imaging Guided Photothermal Therapy using Functionalized Graphene Nanosheets Anchored with Magnetic Nanoparticles
Kai Yang ,1 Lilei Hu ,1 Xingxing Ma ,2 Shuoqi Ye ,3 Liang Cheng ,1 Xiaoze Shi ,1 Changhui Li ,3 Yonggang Li ,2 and Zhuang Liu *1
1Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices Institute of Functional Nano & Soft Materials Laboratory (FUNSOM) Soochow University, Suzhou, Jiangsu 215123, China
2Department of Radiology the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China
3Department of biomedical engineering college of engineering, Peking University, Beijing, 100871, China
In this work, a nanoscale reduced graphene oxide–iron oxide nanoparticle (RGO–IONP) complex is noncovalently functionalized with polyethylene glycol (PEG), obtaining a RGO–IONP–PEG nanocomposite with excellent physiological stability, strong NIR optical absorbance, and superparamagnetic properties. Using this theranostic nanoprobe, in-vivo triple modal fluorescence, photoacoustic, and magnetic resonance imaging are carried out, uncovering high passive tumor targeting, which is further used for effective photothermal ablation of tumors in mice.