YIN, Lichen


Lichen Yin

Ph.D., Professor

Email: lcyin@suda.edu.cn

Tel: 0512-65882039

Academic History:

B.S., Fudan University, School of Life Sciences, 2005.7

Ph.D., Fudan University, School of Life Sciences, 2010.7

Postdoctoral research fellow, University of Illinois at Urbana-Champaign, Dept. of Materials Science and Engineering, 2010.11-2014.1

Professor, Soochow University, since 2014.1


Research Interests:

(1)Development and application of functional biomaterials including helical polypeptides and water-soluble polyesters. Design and develop synthetic or natural polymers for drug delivery, tissue engineering, regenerative medicine, and biosensors. Explore the mechanisms underlying material-organism interactions.

(2)Development of novel drug delivery systems. Explore the fabrication, assembly, therapeutic efficacy, and biological mechanisms of delivery systems for proteins/peptides, nucleic acids, and anti-cancer drugs.

(3)Anti-cancer and anti-inflammation therapies. Design novel therapeutic strategies toward cancer and inflammation, such as the combination of chemotherapy, photothermal therapy, and immunotherapy, and co-delivery of nucleic acids and small molecular anti-cancer drugs.


Research Accomplishments:

Mainly focused on the development of novel drug delivery systems based on polysaccharides, synthetic polypeptides and polyesters for anti-cancer and anti-inflammation therapies. Published over 70 peer-reviewed papers in Nat Chem Biol, Nat Commun, Angew Chem Int Ed, Adv Mater, Chem Sci, Biomaterials, and J Control Release, with a total non-self citation of over 2300 and an H-index of 17. Serve as the invited reviewer for JACS, Adv Mater, Biomaterials, Biomacromolecules, Acta Biomater, etc.



Graduate student: We actively recruit graduate students with background in organic/polymer/materials chemistry, biomaterials, biology, and pharmaceutical science. If you are interested, please contact Prof. Lichen Yin (lcyin@suda.edu.cn) with your CV attached.


Postdoctoral research associate: We have immediate openings for 2-3 postdoctoral scientists with PhD training in polymer chemistry, biomaterials, and drug/gene delivery. Ideal candidates are expected to perform research independently and can help supervise the graduate students. Experience of basic techniques in organic/polymer synthesis, nanofabrication, cell culture, and animal experiments is preferred. To apply for the postdoctoral position, please forward your CV and contact information of three referees directly to Professor Lichen Yin at lcyin@suda.edu.cn.


Assistant/Associated Professor: We have 2 positions for assistant/associate professors in Prof. Yin’s group. Ideal candidates are expected to have background in polymer chemistry, biomaterials, nanomedicine, and drug/gene delivery. If interested, please send your CV, a brief summary of research experience along with the name and contact information of three references to Prof. Lichen Yin at lcyin@suda.edu.cn.


Selected Publications (*corresponding author):

1. Ziyuan Song, Rachael A. Mansbach, Hua He, Kuo-Chih Shih, Ryan Baumgartner, Nan Zheng, Xiaochu Ba, Yinzhao Huang, Deepak Mani, Yun Liu, Yao Lin, Mu-Ping Nieh, Andrew L. Ferguson*, Lichen Yin*, Jianjun Cheng*. Nat Commun, 2017, 8:92.

2. Hua Wang, Ruibo Wang, Kaimin Cai, Hua He, Yang Liu, Jonathan Yen, Zhiyu Wang, Ming Xu, Yiwen Sun, Xin Zhou, Qian Yin, Li Tang, Iwona T Dobrucki, Lawrence W Dobrucki, Eric J Chaney, Stephen A Boppart, Timothy M Fan, Stéphane Lezmi, Xuesi Chen*, Lichen Yin*, Jianjun Cheng*. Selective in vivo metabolic cell-labeling-mediated cancer targeting. Nat Chem Biol, 2017, 13, 415-424.

3. Menghua Xiong, Ziyuan Song, Lichen Yin*, Jianjun Cheng*. Bacteria-Assisted Activation of Antimicrobial Polypeptides via Random Coil-to-Helix Transition. Angew Chem Int Ed, in press.

4. Fangfang Li, Yongjuan Li, Zhuchao Zhou, Shixian Lv, Qiurong Deng, Xin Xu, Lichen Yin*. Engineering the Aromaticity of Cationic Helical Polypeptides toward “Self-Activated” DNA/siRNA Delivery. ACS Appl Mater Interfaces, 2017, 9, 23586?23601.

5. Lipeng Zhu, Jessica M. Simpson, Xin Xu, Hua He, Donghui Zhang*, Lichen Yin*. Optimizing the Molecular Characteristics of Cationic Polypeptoids toward Efficient Non-Viral Gene Delivery. ACS Appl Mater Interfaces, 2017, 9, 23476?23486.

6. Nan Zheng, Ziyuan Song, Jiandong Yang, Yang Liu, Fangfang Li, Jianjun Cheng*, Lichen Yin*. Manipulating the Membrane Penetration Mechanism of Helical Polypeptides via Aromatic Modification for Efficient Gene Delivery. Acta Biomater, 2017, 58, 146-157.

7. Shixian Lv, Yuchen Wu, Jingqi Dang, Zhaohui Tang, Ziyuan Song, Sheng Ma, Xiao Wang, Xuesi Chen, Jianjun Cheng*,  Lichen Yin*. Investigation on the controlled synthesis and post-modification of poly-[(N-2-hydroxyethyl)-aspartamide]-based polymers. Polym Chem, 2017, 8, 1872-1877.

8. Benchun Jiang, Hua He, Li Yao, Tong Zhang, Jianping Huo, Wei Sun*, Lichen Yin*. Harmonizing the Intracellular Kinetics toward Effective Gene Delivery Using Cancer Cell-Targeted and Light-Degradable Polyplexes. Biomacromolecules, 2017, 18, 877?885.

9. Kaimin Cai, Andrew Z. Wang, Lichen Yin*, Jianjun Cheng*. Bio-nano interface: The impact of biological environment on nanomaterials and their delivery properties. J Control Release, in press.

10. Hua He, Nan Zheng, Ziyuan Song, Kyung Hoon Kim, Catherine Yao, Rujing Zhang, Chenglin Zhang, Yuhui Huang, Fatih M. Uckun, Jianjun Cheng, Yanfeng Zhang, Lichen Yin*. Suppression of Hepatic Inflammation via Systemic siRNA Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide Hybrid Nanoparticles. ACS Nano, 2016, 10, 1859?1870.

11. Hua Wang, Li Tang, Yang Liu, Iwona T. Dobrucka, Lawrence W. Dobrucki, Lichen Yin*, Jianjun Cheng*. In Vivo Targeting of Metabolically Labeled Cancers with Ultra-Small Silica Nanoconjugates. Theranostics, 2016, 6, 1467-1476.

12. Hua He, Yugang Bai, Jinhui Wang, Qiurong Deng, Lipeng Zhu, Fenghua Meng, Zhiyuan Zhong*, and Lichen Yin*. Reversibly cross-linked polyplexes enable cancer-targeted gene delivery via self-promoted DNA release and self-diminished toxicity. Biomacromolecules, 2015, 16, 1390-1400.

13. Nan Zheng, Ziyuan Song, Yang Liu, Rujing Zhang, Ruoyan Zhang, Catherine Yao, Fatih M. Uckun, Lichen Yin*, Jianjun Cheng*. Redox-responsive, reversibly-crosslinked thiolated cationic helical polypeptides for efficient siRNA encapsulation and delivery. J Control Release, 2015, 205, 231-239.

14. Xiaojian Deng, Nan Zheng, Ziyuan Song, Lichen Yin*, Jianjun Cheng*. Trigger-responsive, fast-degradable poly(β-amino ester)s for enhanced DNA unpackaging and reduced toxicity. Biomaterials, 2014, 35, 5006-5015.

15. Rujing Zhang, Nan Zheng, Ziyuan Song, Lichen Yin*, Jianjun Cheng*. The effect of side-chain functionality and hydrophobicity on the gene delivery capabilities of cationic helical polypeptides. Biomaterials, 2014, 35, 3443-3454.

16. Lichen Yin, Xin Zhao, Shizhao Ji, Chunbai He, Guangyi Wang*, Cui Tang*, Shaohua Gu*, Chunhua Yin. The use of gene activated matrix to mediate effective SMAD2 gene silencing against hypertrophic scar. Biomaterials, 2014, 35, 2488-2498.

17. Lichen Yin, Ziyuan Song, Kyung Hoon Kim, Nan Zheng, Nathan P. Gabrielson, Jianjun Cheng*. Non-viral gene delivery via membrane-penetrating, mannose-targeting supramolecular self-assembled nanocomplexes. Adv Mater, 2013, 25, 3063-3070.

18. Lichen Yin?, Haoyu Tang#, Kyung Hoon Kim, Nan Zheng, Ziyuan Song, Nathan P. Gabrielson, Hua Lu, Jianjun Cheng*. Trigger-responsive helical polypeptides capable of reducing toxicity and unpacking DNA: toward nonviral gene delivery. Angew Chem Int Ed, 2013, 52, 9182-9186.

19. Lichen Yin, Ziyuan Song, Qiuhao Qu, Kyung Hoon Kim, Nan Zheng, Catherine Yao, Isthier Chaudhury, Haoyu Tang, Nathan P. Gabrielson, Fatih M. Uckun, Jianjun Cheng*. Supramolecular self-assembled nanoparticles mediate oral delivery of therapeutic TNF-α siRNA against systemic inflammation. Angew Chem Int Ed, 2013, 52, 5757–5761.

20. Lichen Yin, Ziyuan Song, Kyung Hoon Kim, Nan Zheng, Haoyu Tang, Hua Lu, Nathan P. Gabrielson, Jianjun Cheng*. Reconfiguring the architectures of cationic helical polypeptides to control non-viral gene delivery. Biomaterials, 2013, 34, 2340-2349.

Edited by Juan Yang


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