Education and Research History:
B.S., Peking University, College of Life Sciences, 2003
Ph.D., University of Texas, Southwestern Medical Center, Dallas, TX, USA, Genetics and Development, 2011
Post-Doc., University of Texas, Southwestern Medical Center, Dallas, TX, USA, Genetics and Development, 2011
Senior Scientist, OriGene technologies, 2011-2012
Director, OriGene technologies, 2013-2014
Professor, Soochow University, since 2014
2. Studying the molecular mechanism of “stemness” in cancer stem cells and normal adult stem cells.
3. Immuno-based tumor detection and therapy
4. Using nano-materials to trace or target cancer cells in vivo
Research Experience and Accomplishments:
Mainly focused on studying the cell of origin and cancer stem cell theory in mouse model of gliomas. Published 16 peer-reviewed papers with total citation exceeded 1600 (Google Scholar). Many publications have been recommended by Faculty of 1000. In 2013, the paper on Nature was reported by BBC, NPR, China Daily and more than 150 other media globally; it was selected as one of the world’s top10 annual scientific breakthrough by Chinese Academic of Sciences （http://news.sciencenet.cn/htmlnews/2013/1/274159.shtm)
1. Mo W, Chen J, Patel A, Zhang L, Chau V, Li Y, Cho W, Lim K, Xu J, Lazar AJ, Creighton CJ, Bolshakov S, McKay RM, Lev D, Le LQ, Parada LF (2013). CXCR4/CXCL12 Mediate Autocrine Cell- Cycle Progression in NF1-Associated Malignant Peripheral Nerve Sheath Tumors. Cell. 152(5):1077-90
2. Chen J, Li Y, Yu TS, McKay RM, Burns DK, Kernie SG, Parada LF (2012). A restricted cell population propagates glioblastoma growth after chemotherapy. Nature. 488(7412):522-6.
(Selected by Faculty of 1000; the discovery was reported by BBC, NPR, China Daily and more than 150 other media globally; it was selected as one of the world’s top10 annual scientific breakthrough by Chinese Academic of Sciences http://news.sciencenet.cn/htmlnews/2013/1/274159.shtm)
3. Chen J, Mckay RM, Parada LF (2012). Malignant glioma: lessons from genomics, mouse models, and stem cells. Cell. 30;149(1):36-47.
4. Blaiss CA, Yu TS, Zhang G, Chen J, Dimchev G, Parada LF, Powell CM, Kernie SG (2011). Temporally specified genetic ablation of neurogenesis impairs cognitive recovery after traumatic brain injury. J Neurosci. 31(13):4906-16.
5. Alcantara Llaguno S*, Chen J*, Kwon CH*, Jackson EL, Li Y, Burns DK, Alvarez-Buylla A, Parada LF (2009). Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell. 15:45-56. (*, Authorship equally shared)
(Selected by Faculty of 1000)
6. Chen J*, Kwon CH*, Lin L, Li Y, Parada LF (2009). Inducible site-specific recombination in neural stem/progenitor cells. Genesis. 47(2):122-31. (*, Authorship equally shared)
7. Alcantara Llaguno SR, Chen J, Parada LF (2009). Signaling in malignant astrocytomas: role of neural stem cells and its therapeutic implications. Clin Cancer Res 1;15(23):7124-9.
8. Lin L, Chen J, Richardson, Parada LF (2009). Mice lacking neurofibromin develop gastric hyperplasia. Am J physiol Gastriointest Liver Physiol. 297: G751-G761
9. Llaguno SA, Chen J, Kwon CH, Parada LF (2008). Neural and Cancer Stem Cells in Tumor Suppressor Mouse Models of Malignant Astrocytoma. Cold Spring Harb Symp Quant Biol. 73:421-6.
10. Li Y, Luikart BW, Birnbaum S, Chen J, Kwon CH, Kernie SG, Bassel-Duby R, Parada LF (2008). TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment. Neuron. 59:399-412.
(Selected by Faculty of 1000)
11. Kwon CH, Zhao D, Chen J, Alcantara S, Li Y, Burns DK, Mason RP, Lee EY, Wu H, Parada LF (2008). Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res. 68:3286-94.
12. Lush ME, Li Y, Kwon CH, Chen J, Parada LF (2008). Neurofibromin is required for barrel formation in the mouse somatosensory cortex. J Neurosci. 28:1580-7.
13. Wang P*, Chen J*, Zheng A*, Nie Y, Shi X, Wang W, Wang G, Luo M, Liu H, Tan L, Song X, Wang Z, Yin X, Qu X, Wang X, Qing T, Ding M, Deng H (2004). Expression cloning of functional receptor used by SARS coronavirus. Biochem Biophys Res Commun. 315:439-44. (*,Authorship equally shared)
14. Yi L, Li Z, Yuan K, Qu X, Chen J, Wang G, Zhang H, Luo H, Zhu L, Jiang P, Chen L, Shen Y, Luo M, Zuo G, Hu J, Duan D, Nie Y, Shi X, Wang W, Han Y, Li T, Liu Y, Ding M, Deng H, Xu X (2004). Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells. J Virol. 78:11334-9.
15. Nie Y, Wang P, Shi X, Wang G, Chen J, Zheng A, Wang W, Wang Z, Qu X, Luo M, Tan L, Song X, Yin X, Chen J, Ding M, Deng H (2004). Highly infectious SARS-CoV pseudotyped virus reveals the cell tropism and its correlation with receptor expression. Biochem Biophys Res Commun. 321:994-1000.
16. Yuan K, Yi L, Chen J, Qu X, Qing T, Rao X, Jiang P, Hu J, Xiong Z, Nie Y, Shi X, Wang W, Ling C, Yin X, Fan K, Lai L, Ding M, Deng H (2004). Suppression of SARS-CoV entry by peptides corresponding to heptad regions on spike glycoprotein. Biochem Biophys Res Commun. 319:746-52.
Edited by Juan Yang