CHENG, Liang

time:2017-07-17Hits:77设置

Liang Cheng, PhD

Associate Professor

  

Institute of Functional Nano & Soft Materials (FUNSOM)

Soochow University, Suzhou, Jiangsu, 215123, China

Email: lcheng2@suda.edu.cnchengliang2009@126.com

  

Professional Activities

2014.7 - Now, Associate Professor, Institute of Functional Nano & Soft Material

                      (FUNSOM), Soochow University, Suzhou, Jiangsu, China

2012.8-2014.6, Lecturer, Institute of Functional Nano & Soft Material (FUNSOM),

                      Soochow University, Suzhou, Jiangsu, China

  

Education
2009-2012    Soochow University, Ph. D. in Chemistry

2006-2009    Anhui Normal University, Master in Chemistry

2002-2006    Anhui Polytechnic University, B. S. in Chemistry

  

Research Experiences and Accomplishments
In the past few years, Dr. Cheng's research work was mainly focused on the synthesis and biomedical applications of upconversion nanoparticles and multifunctional composite nanoparticles, under the supervision by Prof. Liu. Starting From 2008, Dr. Cheng has published over 100 SCI papers (Citation > 5500, H-index =41). His current research interest is the development of multifunctional nanoparticles for applications in biomedical imaging, drug delivery, and combined therapy of cancer.

  

1) TMDCs nanomaterials designed and applied in imaging and combined therapy.

2) Multifunctional nanomaterials designed and applied in theranostic.

3) Ultra-small nanomaterials synthesis and bio-application.

  

Selected Publications

[38Cheng, L.*; Jiang, D.; Kamkaew, A.; Valdovinos, H. F.; Im, H.-J.; Feng, L.; England, C. G.; Goel, S.; Barnhart, T. E.; Liu, Z.; Cai, W.* Renal-Clearable PEGylated Porphyrin Nanoparticles for Image-Guided Photodynamic Cancer Therapy. Adv. Funct. Mater., 2017, In press

[37] Chen, Y.; Cheng, L.; Dong, Z.; Chao, Y.; Lei, H.; Zhao, H.; Wang, J.; Liu, Z*. Degradable Vanadium Disulfide Nanostructures with Unique Optical and Magnetic Functions for Cancer Theranostics. Angew. Chem. Inter. Ed., 2017, In press.

[36] Jin, Q.; Zhu, W.; Jiang, D.; Zhang, R.; Kutyreff, C. J.; Engle, J. W.; Huang, P.; Cai, W.*; Liu, Z.; Cheng, L. Ultra-small iron-gallic acid coordination polymer nanoparticles for chelator-free labeling of 64Cu and multimodal imaging-guided photothermal therapy. Nanoscale2017, 9, 12609-12617.

[35] Shen, S.; Jiang, D.; Cheng, L.*; Chao, Y.; Nie, K.; Dong, Z.; Kutyreff, C. J.; Engle, J. W.; Huang, P.; Cai, W.*; Liu, Z.* Renal-Clearable Ultrasmall Coordination Polymer Nanodots for Chelator-Free 64Cu-Labeling and Imaging-Guided Enhanced Radiotherapy of Cancer. ACS Nano2017. In press.

[34] Shen, S.; Chao, Y.; Dong, Z.; Wang, G.; Yi, X.; Song, G.; Yang, K.; Liu, Z.; Cheng, L. Bottom-Up Preparation of Uniform Ultrathin Rhenium Disulfide Nanosheets for Image-Guided Photothermal Radiotherapy. Adv. Funct. Mater.2017, 27, In press.

[33] Xuan, J., Wang, Z., Chen, Y., Liang, D., Cheng, L.*, Yang, X., Liu, Z., Ma, R., Sasaki, T., Geng F.*, Organic-Base-Driven Intercalation and Delamination for the Production of Functionalized Titanium Carbide Nanosheets with Superior Photothermal Therapeutic Performance. Angew. Chem. Inter. Ed., 2016, 128, 14789-14794.

[32] Cheng, L.*; Kamkaew, A.; Sun, H.; Jiang, D.; Valdovinos, H. F.; Gong, H.; England, C. G.; Goel, S.; Barnhart, T. E.; Cai, W.* Dual-Modality Positron Emission Tomography/Optical Image-Guided Photodynamic Cancer Therapy with Chlorin e6-Containing Nanomicelles.ACS Nano2016.10, 7721-7730

[31] Cheng,L.; Kamkaew, A.; Shen, S. D.; Valdovinos, F. H.; Sun, H.Y.; Hernandez, R.; Goel, S.; Liu, T.; Thompson, R. C.; Barnhart, E. T.; Liu, Z.*, and Cai W. B.*. Facile Preparation of Multifunctional WS2/WOx Nanodots for Chelator-Free 89Zr-Labeling and In Vivo PET Imaging. Small, 2016, 12, 5750-5758

[30] Cheng, L.*; Shen, S.; Shi, S.; Yi, Y.; Wang, X.; Song, G.; Yang, K.; Liu, G.; Barnhart, T. E.; Cai, W.; Liu, Z. FeSe2-Decorated Bi2Se3 Nanosheets Fabricated via Cation Exchange for Chelator-Free 64Cu-Labeling and Multimodal Image-Guided Photothermal-Radiation Therapy. Adv. Funct. Mater., 2016, 26, 2185-2197.

[29] Kamkaew, A.+, Cheng, L.+, Goel, S., Valdovinos, F., Barnhart, E., Liu, Z., Cai W.,*, Cerenkov Radiation Induced Photodynamic Therapy Using Chlorin e6-Loaded Hollow Mesoporous Silica Nanoparticles, ACS Appl. Mater. Interfaces 2016, 8, 26630-26637 (equal contribution).

[28] Chao, Y.; Wang, G.; Liang, C.; Yi, X.; Zhong, X.; Liu, J.; Gao, M.; Yang, K.*; Cheng, L.*; Liu, Z.* Rhenium-188 Labeled Tungsten Disulfide Nanoflakes for Self-Sensitized, Near-Infrared Enhanced Radioisotope Therapy. Small2016, 12, 3967-3975.

[27] Liu, T.; Chao, Y.; Gao M.; Liang C.; Chen, Q.; Song, G. S.; Cheng, L.*; Liu, Z.. Ultra-small MoS2 nanodots with rapid body clearance for photothermal cancer therapy, Nano Res., 2016, 9, 3003-3017

[26] Hao, J.; Song, G.; Liu, T.; Yi, X.; Yang, K.; Cheng, L.*; Liu, Z.* In Vivo Long-Term Biodistribution, Excretion, and Toxicology of PEGylated Transition-Metal Dichalcogenides MS2 (M = Mo, W, Ti) Nanosheets. Adv. Sci.2016, 4, 1600160.

[25] Fu, T.T., Chen, Y.Y. Hao, J.L., Wang, X.Y., Liu, G., Li, Y. G.*, Liu, Z., Cheng, L.*, Facile preparation of uniform FeSe2 nanoparticles for PA/MR dual-modal imaging and photothermal cancer therapy, Nanoscale, 2015, 7, 20757-20768

[24] Cheng, L.*, Yuan, C., Shen, S.D, Yi, X., Gong, H., Yang, K., Liu, Z.*, “Bottom-Up Synthesis of Metal-Ion-Doped WS2 Nanoflakes for Cancer Theranostics”, ACS Nano, 2015, 9, 11090-11101.

[23] Gong, Q.F?, Cheng, L?, Liu, C.H., Zhang, M., Feng, Q.L., Ye, H.L., Zeng, M., Xie, L.M., Liu, Z*, Li, Y.G.*, “Ultrathin MoS2(1–x)Se2x Alloy Nanoflakes For Electrocatalytic Hydrogen Evolution Reaction” ACS Catal., 2015 ,5, 2213-2219

[22] Zhu, W.W, Liu, K., Sun, X.Q, Wang, X., Li, Y.G, Cheng, L.*, Liu, Z., “Mn2+-Doped Prussian Blue Nanocubes for Bimodal Imaging and Photothermal Therapy with Enhanced Performance”, ACS Appl. Mater. Interfaces, 2015, 27, 11575-11582.

[21] Cheng, L.; Wang, C.; Feng, L.Z.; Yang, K.; Liu, Z.*, Functional Nanomaterials for Phototherapies of Cancer. Chem. Rev., 2014, 114, 10869-10939.

[20] Cheng, L.; Huang, W.; Gong, Q.; Liu, C.; Liu, Z.*; Li, Y.G*; Dai, H., Ultrathin WS2 Nanoflakes as a High-Performance Electrocatalyst for the Hydrogen Evolution Reaction. Angew. Chem. Int. Ed.2014,53 , 7860-7863(Back cover, hot article)

[19] Cheng, L.*; Gong, H.; Zhu, W.; Liu, J.; Wang, X.; Liu, G*.; Liu, Z*., PEGylated Prussian blue nanocubes as a theranostic agent for simultaneous cancer imaging and photothermal therapy. Biomaterials,2014,35, 9844-9852.

[18] Song, X.; Gong, H.; Liu, T.; Cheng, L.*; Wang, C.; Sun, X.; Liang, C.; Liu, Z.*, J-Aggregates of Organic Dye Molecules Complexed with Iron Oxide Nanoparticles for Imaging-Guided Photothermal Therapy Under 915-nm Light. Small 2014,10, 4362-4370.

[17] Wang, X.; Liu, K.; Yang, G.; Cheng, L.*; He, L.; Liu, Y.; Li, Y.; Guo, L.; Liu, Z.*, Near-infrared light triggered photodynamic therapy in combination with gene therapy using upconversion nanoparticles for effective cancer cell killing. Nanoscale2014,6, 9198-9205;

[16] Shen, J.; Li, K.; Cheng, L.*; Liu, Z.; Lee, S.-T.; Liu, J.*, Specific Detection and Simultaneously Localized Photothermal Treatment of Cancer Cells Using Layer-by-Layer Assembled Multifunctional Nanoparticles. ACS Appl. Mater.Interfaces2014,6 , 6443-6452;.

[15] Cheng, L.; Liu, J.J.; Gu, X.; Gong, H., Shi, X.Z.; Liu, T., Wang, C., Wang, X.Y., Liu, G.; Xing, H.Y.; Bu, W.B.; Sun, B.Q.; Liu, Z*., PEGylated WS2 nanosheets as a multifunctional theranostic agent for in vivo dual-modal CT / photoacoustic imaging guided photothermal therapy. Adv. Mater.,2014, 26, 1886-1893,(inside cover).

[14] Cheng, L.; He, W.; Gong, H.; Wang, C.; Chen, Q.; Cheng, Z.; Liu, Z., PEGylated Micelle Nanoparticles Encapsulating a Non-Fluorescent Near-Infrared Organic Dye as a Safe and Highly-Effective Photothermal Agent for In Vivo Cancer Therapy. Adv. Funct. Mater., 2013,23, 5893-5902. (Highlighted by Materials Views and Materials Views China)

[13] Cheng, L.; Wang, C.; Ma, X.; Wang, Q.; Cheng, Y.; Wang, H.; Li, Y.; Liu, Z*., Multifunctional Upconversion Nanoparticles for Dual-modal Imaging Guided Stem Cell Therapy under Remote Magnetic Control. Adv. Funct. Mater.2013, 23, 272-280.

[12] Cheng, L; Wang, C.; Liu, Z*., Upconversion nanoparticles and their composite nanostructures for biomedical imaging and cancer therapy. Nanoscale2013, 5, 23-37.

[11] Liu, Z.; Cheng, L*.; Zhang, L.; Yang, Z.; Liu, Z*.; Fang, J.*, Sub-100 nm hollow Au-Ag alloy urchin-shaped nanostructure with ultrahigh density of nanotips for photothermal cancer therapy. Biomaterials 2014,35, 4099-4107.

[10] Liu, Y.; Yang, K.; Cheng, L*.; Zhu, J.; Ma, X.; Xu, H.; Li, Y.; Guo, L.; Gu, H.; Liu, Z*., PEGylated FePt@Fe2O3 core-shell magnetic nanoparticles: Potential theranostic applications and in vivo toxicity studies. Nanomedicine: Nanotechnology, Biology and Medicine2013,9 (7), 1077-1088.

[9] Yin, S.; Li, Z.; Cheng, L* Wang, C.; Liu, Y.; Chen, Q.; Gong, H.; Guo, L.; Li, Y.; Liu, Z., Magnetic PEGylated Pt3Co nanoparticles as a novel MR contrast agent: in vivo MR imaging and long-term toxicity study. Nanoscale2013, 5, 12464-12473.

[8] Cheng, L.; Yang, K.; Li, Y.; Zeng, X.; Shao, M.; Lee, S.-T.; Liu, Z*., Multifunctional nanoparticles for upconversion luminescence/MR multimodal imaging and magnetically targeted photothermal therapy. Biomaterials2012, 33, 2215-2222.

[7] Cheng, L.; Yang, K.; Chen, Q.; Liu, Z*., Organic nanoparticles for ultra-effective in vivo near-infrared photothermal therapy of cancer. ACS Nano2012, 6, 5605-5613, (Highlighted by C&E News ).

[6] Cheng, L.; Yang, K.; Li, Y.; Chen, J.; Wang, C.; Shao, M.; Lee, S.-T.; Liu, Z*., Facile preparation of multifunctional upconversion nanoprobes for multi-modal imaging and dual-targeted photothermal therapy. Angew. Chem. Int. Ed2011, 50, 7385-7390.

[5] Cheng, L.; Yang, K.; Lu, X.; Shao, M.; Liu, Z*., In vivo Pharmacokinetics, Long-term Biodistribution and Toxicology Study of Functionalized Upconversion Nanoparticles in Mice. Nanomedicine2011, 6, 1327-1340

[4] Cheng, L.; Yang, K.; Shao, M.; Lee, S.-T.; Liu, Z*., Multicolor In Vivo Imaging of Upconversion Nanoparticles with Emissions Tuned by Luminescence Resonance Energy Transfer. J. Phys. Chem. C2011, 115, 2686-2692

[3] Cheng, L.; Yang, K.; Zhang, S.; Shao, M.; Lee, S., Liu, Z.*,Highly-sensitive Multiplexed in vivo Imaging Using PEGylated Upconversion Nanoparticles. Nano Res2010, 3, 722-732.

[2] Cheng, L.; Shao, M*.; Wang, X.; Hu, H., Single-Crystalline Molybdenum Trioxide Nanoribbons: Photocatalytic, Photoconductive, and Electrochemical Properties. Chem. Eur. J. 2009, 15, 2310-2316.

[1] Cheng, L.; Shao, Q.; Shao, M*.; Wei, X.; Wu, Z., Photoswitches of One-Dimensional Ag2MO4 (M) Cr, Mo, and W). J. Phys. Chem. B 2009, 113, 1764-1768


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