ACS Nano: Photothermally Enhanced Photodynamic Therapy Delivered by Nano-Graphene Oxide

time:2011-08-12Hits:49设置

Title:

Photothermally Enhanced Photodynamic Therapy Delivered by Nano-Graphene Oxide

Author:

Bo Tian, Chao Wang, Shuai Zhang, Liangzhu Feng, and Zhuang Liu*

Institution:

Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu, 215123, People's Republic of China

Abstract:

Graphene with unique physical and chemical properties has shown various potential applications in biomedicine. In this work, a photosensitizer molecule, Chlorin e6 (Ce6), is loaded on polyethylene glycol (PEG)-functionalized graphene oxide (GO) via supramolecular ππ stacking. The obtained GO-PEG-Ce6 complex shows excellent water solubility and is able to generate cytotoxic singlet oxygen under light excitation for photodynamic therapy (PDT). Owing to the significantly enhanced intracellular trafficking of photosensitizers, our GO-PEG-Ce6 complex offers a remarkably improved cancer cell photodynamic destruction effect compared to free Ce6. More importantly, we show that the photothermal effect of graphene can be utilized to promote the delivery of Ce6 molecules by mild local heating when exposed to a near-infrared laser at a low power density, further enhancing the PDT efficacy against cancer cells. Our work highlights the promise of using graphene for potential multifunctional cancer therapies.

IF:

9.855



                                                                     Editor: Danting Xiang




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