Supramolecular Stacking of Doxorubicin on Carbon Nanotubes for in vivo Cancer Therapy
|Zhuang Liu1,4┼, Alice C. Fan2┼, Kavya Rakhra2, Sarah Sherlock1, Andrew Goodwin1, Xiaoyuan Chen3, Qiwei Yang2, Dean W. Felsher2*and Hongjie Dai1*|
1Department of Chemistry, StanfordUniversity, Stanford, CA, USA
2Division of Oncology, StanfordUniversitySchool of Medicine, Stanford, CA, USA
3Department of Radiology, StanfordUniversitySchool of Medicine, Stanford, CA, USA
4Functional Nano & Soft Materials Laboratory (FUNSOM), SoochowUniversity, Suzhou, Jiangsu, China
In this work, we report that supramolecular π-π stacking provides a novel approach for highly efficient loading of a chemotherapeutic agent, doxorubicin (DOX), onto the sidewalls of functionalized single walled carbon nanotubes (SWNTs). With a human lymphoma mouse xenograft model, the SWNT-DOX formulation shows many therapeutic advantages over free DOX including prolonged circulation in the blood, increased tumor drug uptake, enhanced therapeutic efficacy and markedly reduced toxic side effects. Pilot study of SWNT-DOX vs. DOXIL with the mouse tumor model is also carried out.
Editor: Danting Xiang