Presenter： Prof. Jin Zhang, University of California
Topic：Illuminating the Biochemical Activity Architecture of the Cell
Time：2：00 PM, October 23rd (Tuesday)
Location：Conference Room 308, BLDG 910
Abstract: The complexity and specificity of many forms of signal transduction are widely suspected to require spatial microcompartmentation and dynamic modulation of the activities of signaling molecules, such as protein kinases, phosphatases and second messengers. We have developed a series of fluorescent biosensors to probe the compartmentalized signaling activities in living cells. In this talk, I will present several new fluorescent biosensors that we recently developed; I will then focus on cAMP/PKA and PI3K/Akt/mTORC1 signaling pathways and present studies where we combined genetically encoded fluorescent biosensors, superresolution imaging, targeted biochemical perturbations and mathematical modeling to probe the biochemical activity architecture of the cell.
Prof. Jin Zhanghas been a professor at the University of California, San Diegosince 2015. Prior to joining UCSD, she received her Ph.D. from The University of Chicago in 2000, and then worked at Johns Hopkins University School of Medicine and Whiting School of Engineering from 2003 to 2015. The Zhang group pioneered work on understanding the spatiotemporal regulation of signal transduction in living systems, with extensive experience in signal transduction research and imaging methodology development. Her work has led to publications on many prestigious journals, such as Nature Cell Biology, Nature Methods and PNAS. Prof. Zhanghas received numerous awards including the Fellow of the American Association for the Advancement of Science (AAAS), NIH Director’s Pioneer Award, NCI Outstanding Investigator Award and NSF CAREER Award.
Contact: Prof. Zhuang Liu